What is a pharmacodynamic drug interaction?

Pharmacodynamic interactions These are interactions between drugs which have similar or antagonistic pharmacological effects or side-effects. They might be due to competition at receptor sites, or occur between drugs acting on the same physiological system.

What is the example of pharmacodynamic interaction?

Examples of pharmacodynamic interactions are simultaneous administration of a NSAID and phenprocoumon (additive interaction), or of aspirin and ibuprofen (antagonistic interaction).

What is the cause of pharmacodynamic drug interaction?

Abstract. Pharmacodynamic drug-drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.

What are the 4 stages of pharmacodynamics?

Think of pharmacokinetics as a drug’s journey through the body, during which it passes through four different phases: absorption, distribution, metabolism, and excretion (ADME).

How is pharmacodynamics best defined?

Pharmacodynamics refers to the relationship between drug concentration at the site of action and the resulting effect, including the time course and intensity of thera- peutic and adverse effects. The effect of a drug present at the site of action is determined by that drug’s binding with a receptor.

What are the three main effects associated with pharmacodynamics interaction?

Stimulating activity by directly inhibiting a receptor and its downstream effects. Depressing activity by direct receptor inhibition and its downstream effects.

What are the factors affecting pharmacodynamics?

Disorders that affect pharmacodynamic responses include genetic mutations, thyrotoxicosis, malnutrition, myasthenia gravis, Parkinson disease, and some forms of insulin-resistant diabetes mellitus. These disorders can change receptor binding, alter the level of binding proteins, or decrease receptor sensitivity.

What are pharmacodynamic parameters?

Pharmacodynamic parameters describe the action of the drug on the body. They describe the relationship between drug concentration and the pharmacologic effect. They describe how an antibiotic produces its antimicrobial effects on the microbe as well as any other effects it may produce on the body.