How is albumin anion gap calculated?

Some authors have proposed that the corrected anion gap (cAG)—anion gap corrected for albumin—be used in all critically ill patients. The cAG as proposed by Figge et al is calculated as follows: cAG (mmol/l) = anion gap + 0.25 × (normal albumin − measured albumin) (albumin is measured in g/l) [Equation 2].

How do you calculate the expected anion gap?

Anion Gap Formula Anion gap (AG) = Na+ – (Cl– + HCO3–) = unmeasured anions – unmeasured cations. The AG measures anions that are not normally included in routine electrolyte studies such as sulfates, phosphates, lactic acid, ketones, and other organic acids.

Why is albumin used in anion gap?

Raised serum albumin (hyperalbuminemia) can increase anion gap by the same mechanism that reduced serum albumin (hypoalbuminemia) reduces anion gap [9]. Small increases in anion gap (of the order 4-6 mmol/L) are evident in patients suffering metabolic alkalosis uncomplicated by other acid-base disturbance [25].

What is normal range for anion gap?

Normal results are 3 to 10 mEq/L, although the normal level may vary from lab to lab. If your results are higher, it may mean that you have metabolic acidosis.

Do you correct anion gap for albumin?

Conclusions: The observed anion gap can be adjusted for the effect of abnormal serum albumin concentrations as follows: adjusted anion gap = observed anion gap + 0.25 x ([normal albumin] [observed albumin]), where albumin concentrations are in g/L; if given in g/dL, the factor is 2.5.

Is anion gap and albumin the same?

albumin is the major unmeasured anion and contributes almost the whole of the value of the anion gap. a normally high anion gap acidosis in a patient with hypoalbuminaemia may appear as a normal anion gap acidosis.

What is considered high anion gap?

Although there are differences between laboratories and assays, the normal anion gap has traditionally been set between 8 mEq/L to 12 mEq/L. If the anion gap is greater than 12, this suggests an increased presence of unmeasured anions.

What is a high anion gap number?

Is albumin positive or negative?

Albumin is a globular, water-soluble, un-glycosylated serum protein of approximate molecular weight of 65,000 Daltons. Albumin (when ionized in water at pH 7.4, as found in the body) is negatively charged.